Oncogenic Drivers
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Understand the importance of biomarkers in the management of your patients with NSCLC

oncogenic drivers oncogenic drivers

Oncogenic alterations and your patients with NSCLC…


oncogenic driver alterations identified1


of patients like yours may have an oncogenic alteration2,3


of patients like yours may have an oncogenic MET alteration4,5

With over a dozen oncogenic drivers discovered for NSCLC, testing your patients has never been more important6

These oncogenic driver mutations occur in approximately 50% of patients with NSCLC, including driver mutations such as KRAS, EGFR, ALK, MET and ROS1 alterations (25%, 15%, 5%, 3% and 2%, respectively*).2,3

Estimated alteration frequency* of select oncogenic driver alterations in your patients with NSCLC (%)1,2

*Prevalence of gene mutations varies between studies

References and Abbreviations:

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1. Rossell R, Karachaliou N. Lancet 2016; 387:1354–1356.

2. Pakkala S, Ramalingam SS. JCI Insight 2018; 3:e120858. 

3. Grosse A et al. Diagn Pathol 2019; 14:18. 

4. Salgia R. Mol Cancer Ther 2017; 16:555–565.

5. Ikeda S et al. J Hematol Oncol 2018; 11:76.

6. Yoda S et al. Pharmacol Ther 2019; 193:20–30. 

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